Antibody Development
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Comprehensive Solutions for Developable lead candidates
Antibody Discovery is only half the journey. Identifying and optimizing the perfect lead candidate requires thorough functional validation and robust developability assessment. To ensure long-term success, antibodies must not only bind their target but also demonstrate functional activity, stability, and manufacturability. These critical steps determine whether a promising molecule can become a true development candidate.
Integrated Functional & Developability Assessment
Whether the antibody was generated by us or provided by our clients, every candidate enters the same rigorous assessment pipeline. Our integrated approach ensures objective comparison, informed decision-making, and confident selection of the best lead candidates using efficient evaluation process.
- Effector function: ADCC, CDC
- ADC testing: cytotoxicity
- Binding studies: ELISA, BLI, flow cytometry
- Affinity measurement
- Epitope binning and mapping
- Other functional tests: receptor inhibition, internalization, competition assays, immune activation, checkpoint inhibition
- SEC-HPLC
- HIC-HPLC
- Melting temperature
- Antibody self-interaction (AC-SINS)
- Polyreactivity
- Stability: serum, buffer, pH & temperature
