Antibody
Libraries
The human antibody repertoire in one tube –
Utilizing Nature’s immune Library for Drug Discovery
Antibody discovery is all about finding the needle in the haystack, i.e. the right sequence that unlocks access to your target of interest. YUMAB’s broad library services and advanced in vitro selection technologies facilitate the identification of novel antibodies and the optimization of existing lead candidates against any target at a high success rate.
Universal YUMAB® libraries contain natural antibody sequences (no synthetic sequences), which are close to the human germline repertoire. These antibody sequences are pre-selected in the human body for low toxicity, immunogenicity, and high productivity, which makes them perfect for the development of therapeutic drugs.
Our Libraries for your Antibody Therapeutics
YUMAB Antibody Libraries are large, highly diverse collections of antibody gene sequences, derived from both natural and immune repertoires, and cloned into vectors optimized for phenotypic screening through phage or mammalian display. In addition to our antibody discovery and development services, we also offer custom library generation.
Universal, Fully Human Naive Antibody Libraries
Built for any target
Our universal, fully human libraries encompass all antibody frameworks without germline or CDR restrictions. This enables the discovery of antibodies against virtually any target with broad epitope and affinity coverage.
Immune Antibody Libraries
Designed for rapid, high-affinity discovery
YUMAB generates custom antigen-specific antibody libraries from human patients or immunized animals different species of different species for the antibody discovery against challenging targets with in-vivo optimized binding affinities.
Single Domain (VHH) Antibody Libraries
Small, stable and convenient building blocks for bi- and multi-specific formats
YUMAB generates antigen-specific single domain (VHH) antibody libraries from immunized llamas or alpacas. For immunization against complex multi-pass TMPs, we use a unique llama-derived cell line transfected with the target of interest to address even challenging targets. These high affinity in-vivo optimized VHH antibodies are used as building blocks of the next generation of multispecific antibody drugs.
Paired Antibody Libraries
Bridging in-vivo and in-vitro
YUMAB’s cutting-edge microfluidic technology for B cell encapsulation allows the isolation of paired heavy and light chains to generate naturally paired antibody Libraries.
Humanized VHH Antibody Libraries
Ready-to-use human single-domain antibodies
YUMAB’s VHH antibody library consists of liability-free humanized VHH frameworks and fully-human CDR sequences to maximize target coverage while reducing immunogenicity and developability risks.
Next Generation Antibody Libraries
For optimized developability
YUMAB’s semi-synthetic antibody libraries combine the natural human antibody diversity with rationally designed synthetic antibody framework that is purged from any sequence liabilities. These libraries provide a flexible platform for the rapid discovery of highly developable antibodies, complementing traditional natural naïve or immune libraries.
